Detection of the Components of the Root of Saussurea Costus and Study of the Effect of the Aqueous Extract of Its Roots on the Kidneys of Male Rats Treated with Chlorpromazine
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Abstract
Saussurea costus (Falc.) Lipsch plant belongs to the Asteraceae family. Its root has traditionally been used to treat a variety of ailments, including strep throat, dysentery, ulcers, and asthma. Studies have shown that S. costus root has a wide range of therapeutic effects, including antioxidant, antitumor, hepatoprotective and anti-inflammatory effects. The preliminary phytochemical screening of S. costus root revealed the presence of resins, flavonoids, alkaloids, saponins, and several other components. Twenty-five Swiss albino rats divided into five groups to study the effects of the extract. The first group represented the negative control group, while the second group was administered Chlorpromazine alone at a concentration of 2 mg/kg once daily. In the third, fourth, and fifth groups, alcoholic extracts of Indian costus root were administered at concentrations of 1.25 mg/kg, 2.4 mg/kg, and 4 mg/kg, respectively. The study showed that costus extract acted as a protective agent against the side effects of Chlorpromazine, particularly in safeguarding the kidneys from symptoms such as infiltration and tissue damage that were caused by the drug used in the treatment.
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Xu B, Xu ZF, Deng Y, Yang JH. Protective effects of chlorpromazine and verapamil against cadmium-induced kidney damage in vivo. Exp Toxicol Pathol. 2010;62(1):27–34.
Bouley R, Yui N, Terlouw A, Cheung PW, Brown D. Chlorpromazine induces basolateral aquaporin-2 accumulation via F-actin depolymerization and blockade of endocytosis in renal epithelial cells. Cells. 2020;9(4):1057.
Shabab ZA. Study of reproductive efficiency and histological changes in liver and kidney associated with subacute and acute dose of chlorpromazine (Largctil) in mice Mus musculus. Univ Thi-Qar J Agric Res. 2020;9(1):97–107.
Apata JT, Ogunbiyi OJ, Animashaun FA, Babalola OO, Igharo EJ, Rotimi J, et al. Nephroprotective effect of ethanolic leaf extract of Clausena anisata against chlorpromazine-induced nephrotoxicity in Wistar rats. J Pharm Drug Dev. 2023;2(1):2836–2322.
Chandra S, Gahlot M, Choudhary AN, Palai S, de Almeida RS, de Vasconcelos JEL, et al. Scientific evidences of anticancer potential of medicinal plants. Food Chem Adv. 2023;100239.
Hameed AT, Dawd SM, Al Bahadly ZK. Ecological study and peroxidase activity of some medicinal plants (Asteraceae) growing wildly in Anbar Governorate, Iraq. J Phys Conf Ser. 2021;1818(1):012037.
Rathore S, Debnath P, Kumar R. Kuth Saussurea costus (Falc.) Lipsch.: a critically endangered medicinal plant from Himalaya. J Appl Res Med Aromat Plants. 2021;20:100277.
Roy A, Khan A, Ahmad I, Alghamdi S, Rajab BS, Babalghith AO, et al. Flavonoids: a bioactive compound from medicinal plants and its therapeutic applications. Biomed Res Int. 2022;2022:5445291.
Singh R, Chahal KK, Singla N. Chemical composition and pharmacological activities of Saussurea lappa: a review. J Pharmacogn Phytochem. 2017;6(4):1298–1308.
Kadi RH. Screening of fatty acids profile and antioxidant activities with the antibacterial activities of Saussurea costus essential oil. J Biobased Mater Bioenergy. 2023;17(1):88–92.
Tousson E, El-Atrsh A, Mansour M, Abdallah A. Modulatory effects of Saussurea lappa root aqueous extract against ethephon-induced kidney toxicity in male rats. Environ Toxicol. 2019;34(12):1277–1284.
Al-Radadi NS. Saussurea costus for sustainable and eco-friendly synthesis of palladium nanoparticles and their biological activities. Arab J Chem. 2022;15(11):104294.
Shaikh SS, Bawazir AS, Yahya BA. Phytochemical, histochemical and in vitro antimicrobial study of various solvent extracts of Costus speciosus and Costus pictus. Turk J Pharm Sci. 2022;19(2):145–152.
Soliman MF, Shetaia YM, Tayel AA, Munshi AM, Alatawi FA, Alsieni MA, et al. Exploring the antifungal activity and action of Saussurea costus root extracts against Candida albicans and non-albicans species. Antibiotics (Basel). 2022;11(3):327.
Gupta M, Sumaiya S, Ali S, Naved T, Sharma A, Ahmad A, et al. Pharmacognostical and phytochemical evaluation of a Unani polyherbal formulation: Dawa ul kurkum by HPTLC. Separations. 2023;10(2):89.
Pandey MM, Rastogi S, Rawat AKS. Evaluation of pharmacognostical characters and comparative morphoanatomical study of Saussurea costus and Arctium lappa roots. Nat Prod Sci. 2007;13(4):304–310.
Kirui A, Widanage MCD, Mentink-Vigier F, Wang P, Kang X, Wang T. Preparation of fungal and plant materials for structural elucidation using dynamic nuclear polarization solid-state NMR. J Vis Exp. 2019;(144):e59152.
Zahnit W, Smara O, Bechki L, Bensouici C, Messaoudi M, Benchikha N, et al. Phytochemical profiling, mineral elements, and biological activities of Artemisia campestris L. grown in Algeria. Horticulturae. 2022;8(10):914.
Soylak M, Koksal M. Deep eutectic solvent microextraction of Pb(II), Co(II), Ni(II) and Mn(II) prior to flame AAS determination. Microchem J. 2019;147:832–837.
Chavan SG, Vemuri N. Diagnosis of breast lumps based on BIRADS score and histopathological examination. Int Surg J. 2020;7(1):144–149.
Ali SI, Venkatesalu V. Botany, traditional uses, phytochemistry and pharmacological properties of Saussurea costus: a review. Phytochem Lett. 2022;47:140–155.
Pandey MM, Rastogi S, Rawat AKS. Saussurea costus: botanical, chemical and pharmacological review. J Ethnopharmacol. 2007;110(3):379–390.
Vijayalakshmi M, Umamaheswari A, Agalya B, Jegasubramaniam SN, Prabu SL. Foresight on phytoconstituents and pharmacological activities of Saussurea costus. Curr Pharmacol Rep. 2022;8(4):281–289.
Hegazy MM, Mostafa RM, El-Sayed YA, Baz MM, Khater HF, Selim A, et al. Efficacy of Saussurea costus extracts against hematophagous arthropods of camel and cattle. Pak Vet J. 2022;42(4):547–553.
Zaky K, Mohamed Y, Ashour A, Zidan T, Hussien TA, Ahmed AS. Pharmacognostical studies on roots of Saussurea costus. Sphinx J Pharm Med Sci. 2022;4(1):15–25.
Elshaer SE, Hamad GM, Hafez EE, Baghdadi HH, El-Demerdash FM, Simal-Gandara J. Root extracts of Saussurea costus as detoxifying food additive against sodium nitrite toxicity. Food Chem Toxicol. 2022;166:113225.
Bouvier ML, Fehsel K, Schmitt A, Meisenzahl-Lechner E, Gaebel W, von Wilmsdorff M. Sex-dependent effects of long-term antipsychotic medication on red blood cells and liver iron metabolism. BMC Pharmacol Toxicol. 2022;23(1):8.
Bouley R, Yui N, Terlouw A, Cheung PW, Brown D. Chlorpromazine induces basolateral aquaporin-2 accumulation in renal epithelial cells. Cells. 2020;9(4):1057.
Sun H, Zhang L, Sui B, Li Y, Yan J, Wang P, et al. Effect of terpenoid natural Chinese medicine molecular compound on lung cancer treatment. Evid Based Complement Alternat Med. 2021;2021:Article ID.
Hu XF, Liu WX, Zhang R, Zhang W, Wang C, Chen M, et al. Essential oil from Saussurea costus inhibits proliferation and migration of Eca109 cells. Asian Pac J Trop Biomed. 2022;12(6):253–259.
Mammate N, Imtara H, Belchkar S, Benjelloun Touimi G, Al-Zharani M, Rudayni HA, et al. Anti-struvite, antimicrobial and anti-inflammatory activities of Saussurea costus extracts. Molecules. 2023;28(2):667.
El Sayed SM. Natural remedies of prophetic medicine in viral hepatitis management. Am J Clin Med Res. 2023;11(1):14–21.
Gupta M, Nimesh H, Sarwat M. Pharmacological studies of polyherbal formulation Dawa ul kurkum in hepatocellular carcinoma model. bioRxiv. 2023.
Pradhane AP, Methekar RN, Agrawal SG. Melamine-based uric acid kidney stone formation and prevention. Urolithiasis. 2023;51(1):68.
Cheng QQ, Mao SL, Yang LN, Chen L, Zhu JZ, Liu X, et al. Fuzheng Xiaoai Decoction ameliorates cancer cachexia-induced muscle atrophy. J Ethnopharmacol. 2023;303:115944.
Elshaer SE, Hamad GM, Hafez EE, Baghdadi HH, El-Demerdash FM, Simal-Gandara J. Root extracts of Saussurea costus against sodium nitrite toxicity. Food Chem Toxicol. 2022;166:113225.
Elgharabawy RM, El Tantawy El Sayed I, Abd-Allah Rezk N, Tousson E. Therapeutic impact of Saussurea lappa against Ehrlich solid tumor-induced cardiac toxicity. Front Pharmacol. 2021;12:708785.